The Christian cemetery in Aleppo's Aziziye district originated after the 1580s, when the city's Armenian population had significantly increased and burials of laypeople were not permitted in the courtyard of the Forty Martyrs Armenian Cathedral (founded in 1491). As the cemetery expanded, it was divided into three sections, though these were not assigned to specific Christian communities and burials remained intermingled. The oldest tombstones were located along the southern edge. Armenian burials were concentrated in the western part of the first section, most of the second, and the eastern and northern parts of the third.

The tombstones were flat, typically measuring 80–100 cm in length, 50–60 cm in width, and 12–15 cm in height. Notable yellow marble stones in the northern part of the second section were about two-thirds larger than the others. Some tombstones were removed in 1853 for the construction of the Armenian National School and others in 1874 during work on the upper structure of the Forty Martyrs Cathedral.

In 1894, Aleppo's military commander cleared a path through the cemetery for his soldiers by moving tombstones at night, provoking outrage within the Christian community. In response, the regional governor authorized the cemetery to be fenced off to prevent further incidents. It was enclosed with high, wide iron gates.

The cemetery was closed in February 1927 due to health concerns. Land previously allocated to Armenians in the northern Sheikh-Maqsoud district in 1915 for the burial of refugees was then designated as the National Armenian Cemetery to replace Aziziye. Following its closure, Aziziye's area was reduced from 66,200 square meters, according to a 1912 map, to 36,600 square meters by 1935. Some remains were later transferred to the Sheikh-Maqsoud site, including those of Khoja Bedik Chelebi in 1946, a prominent community leader who had been executed in 1627.

In 1947, the entire Aziziye property was sold and residential buildings were constructed on the site. The remaining tombstones were moved to the Sheikh-Maqsoud cemetery, where they remained stacked for decades until, due to lack of space in the 1970s, they were broken up and used as paving within the grounds. During renovations in the early 2000s, inscriptions on the already fragmented stones were scraped off and are no longer visible. These inscriptions had been recorded by Surmeian in a book published prior to the cemetery's destruction. While some individuals named in those inscriptions may have had their remains relocated, most likely did not and would still be at the original site. As a result, they are listed on Findagrave under Aziziye, even though the cemetery no longer exists and their tombstones have been destroyed.

Location: The Findagrave map is pointed to the location where the three sections of the cemetery met. The eastern border of the cemetery ran along Al-Sulaymaniyah Street (شارع السليمانية) to what is now al-Aziziyeh Square on the west. The street running diagonally from Al-Aziziyeh Square southeasterly until intersecting with Qestaki Homsi Street separates what was the cemetery's largest section on the north side (42,500 sq meters) and the central one (13,200 sq meters). The third section consisting in the cemetery's south (10,500 sq meters) can be found on a map bounded by Qestaki Homsi Street on the north, Sheik Litani Street on the west, and down to the intersection of Farazdak and Al-Telal.