Mt. WhitneyCemetery was originally established by the Knights of Pythias in Lone Pine and was made possible by the donation of ranch land for this purpose. The cemetery is located right on California Highway 395, on the northern portion of Lone Pine. It is administered by the Lone Pine Cemetery District and is an active cemetery. Nearby, on the opposite side of Highway 395 is the mass grave cemetery for the victims of the 1872 earthquake.

However, the first cemetery established in Lone Pine is now referred to as the PioneerCemetery. The first burials in this location were Mrs. McGuire and her 9 year old son, Johnny, who were both killed in an Indian attack on 1 January 1865. The PioneerCemetery was the main cemetery in Lone Pine until 1884, and it was still an active cemetery up until the year 1914, though it was never fully utilized.

Used in conjunction with the PioneerCemetery was an informal burying ground which is now referred to as the DepotCemetery. The information about the Depot graves was shared by the cemetery district as to its purpose and use. During the spring season of wet years, when the water table level at the PioneerCemetery was too high to allow for burials there, a temporary burying ground at the northern end of town was utilized, now called the DepotCemetery. Then in late summer, when the water table was lower, burials could be disinterred and moved to the PioneerCemetery. However, there are still grave markers existing today at the DepotCemetery, with about 11 burials identified. The DepotCemetery graves are located adjacent to Lone Pine Narrow Gauge Road and are near the remains of a train depot building which stood near the 1883 Carson & Colorado narrow gauge railroad track which ran from Nevada to the town of Keeler. The few marked graves in the DepotCemetery are scattered informally in an open area of high desert terrain and are easy to miss amongst the vegetation when viewing from Narrow Gauge Road.